![]() Prevention and treatment of HZ complications remain a therapeutic challenge despite recent advances. HZ and its complications (particularly postherpetic neuralgia) create a significant burden for the patient, carers, healthcare systems and employers. Individuals who are immunocompromised as a result of disease or therapy are also at increased risk, independent of age. The age-related increased incidence of HZ and its complications is thought to be a result of the decline in cell-mediated immunity (immunosenescence), higher incidence of comorbidities with age and social-environmental changes. keratitis, iridocyclitis, secondary glaucoma) or visceral (e.g. long-term pain, segmental paresis, stroke), ophthalmological (e.g. secondary bacterial infection), neurological (e.g. Complications may be dermatological (e.g. ![]() ![]() Herpes zoster (HZ) is primarily a disease of nerve tissue but the acute and longer-term manifestations require multidisciplinary knowledge and involvement in their management.
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